Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer.
Tousignant KD, Rockstroh A, Poad BLJ, Talebi A, Young RSE, Taherian Fard A, Gupta R, Zang T, Wang C, Lehman ML, Swinnen JV, Blanksby SJ, Nelson CC, Sadowski MC.
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Cancer Metab. 2020 Jun 19;8:11. doi: 10.1186/s40170-020-00217-6. eCollection 2020.
Cancer Metab. 2020.
PMID: 32577235
Free PMC article.
The rise in membrane PUFA levels enhanced membrane fluidity and lipid peroxidation, causing hypersensitivity to glutathione peroxidase (GPX4) inhibition and ferroptosis. Combination treatments against AR and fatty acid desaturation, lipase activities, or growth medium supp …
The rise in membrane PUFA levels enhanced membrane fluidity and lipid peroxidation, causing hypersensitivity to glutathione peroxidase (GPX4 …